Founded by brigham and women's hospital and massachusetts general hospital

Office of Continuing Professional Development

Lyme Borreliosis and Tick Borne Illnesses: Diagnostics, Emerging Pathogens and Avenues for New Research

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Saturday, November 8 - Sunday, November 9, 2014

Massachusetts General Hospital
O'Keeffe Auditorium
55 Fruit Street

Boston, MA 02114



This live symposium will include presentations from leading investigators on Lyme disease and tick borne infections emphasizing our current understanding and avenues for new research. The conference will be a valuable continuing educational experience for internists, pediatricians, infectious disease specialists and pathologists. The conference will have six sessions:

1. Plenary overview lectures on Lyme disease in the northeast, across America and Europe.
2. Overview of the Lyme spirochete including phylogeny, molecular and cell surface protein biology
3. Co-infections with Lyme disease
4. Host pathogen interactions in Lyme disease
5. Diagnostic testing: current and future status
6. Special topics in tick borne infections

Learning Objectives

Upon completion of this activity, participants will be able to:

1. Identify the epidemiology, ecology, molecular, and cell surface protein biochemistry of the Lyme spirochete.
2. Cite host-pathogen interactions in Lyme disease.
3. Describe the performance characteristics, pitfalls, and inadequacies of current testing for tick borne illnesses.

Target Audience

This activity is intended for physicians in general internal medicine, primary care, infectious disease, and neurology, as well as interested residents and fellows.


This is a draft agenda. Speakers and titles are subject to change.


7:30 a.m.

Continental Breakfast

8:00 a.m.

Welcome and Opening Remarks
Kent Lewandrowski, MD
Massachusetts General Hospital

Plenary Lectures:


An overview of tick-borne diseases, emerging pathogens and important areas of future research
Allen Steere, MD
Massachusetts General Hospital

8:45 a.m.

Lyme Disease in the United States
Paul Mead, MD, MPH
Centers for Disease Control


Lyme Disease in Europe
Franc Strle, MD
University Medical Centre, Slovenia

9:45 a.m.

Lyme Disease in Massachusetts
Alfred DeMaria, MD
Massachusetts Department of Public Health

10:15 a.m.

Questions & Answers

10:30 a.m.


Overview of tick-borne diseases: Clinical presentations, microbiology, phylogenetics and new areas for potential research

Session 1: Overview of the Lyme spirochete

10:45 a.m

Ecology of Lyme disease
Sam Telford, DSc
Cummings School of Veterinary Medicine

11:15 a.m.

Cell surface lipoprotein succession in Borrelia burgdorferi in different stages of the bacterial life cycle and infection
Xin Li, PhD
Tufts Medical Center

11:45 a.m.

Questions & Answers

11:55 a.m.

Lunch (provided in the Eat Street Cafe, Garden Room)

Session 2: Co-infections and tick-borne diseases other than Lyme disease: Clinical presentations, microbiology, laboratory diagnosis, and areas of new research

12:45 p.m.

Powassan virus and Borrelia miyamotoi
Sam Telford, DSc
Cummings School of Veterinary Medicine

1:15 p.m.

Anaplasmosis and Babesiosis
Peter Krause, MD
Yale University

2:00 p.m.

Questions & Answers

2:10 p.m.


Session 3: Host pathogen interactions in Lyme disease

2:15 p.m.

Factors influencing pathogenicity and virulence of Borrelia burgdorferi
Ira Schwartz, PhD
New York Medical Center

2:45 p.m.

Sequencing answers to host-pathogen interactions in Lyme Disease: applying next-generation sequencing to identify virulence determinants in Borrelia burgdorgeri
Linden Hu, MD
Tufts Medical Center

3:15 p.m.

Cytokines and chemokines as biomarkers of the innate and adaptive immune response to Borrelia burgdorferi
Klemen Strle, PhD
Massachusetts General Hospital

3:45 p.m.

Immune dysregulation in Lyme disease
Elise Drouin, PhD
Massachusetts General Hospital

4:15 p.m.


4:30 p.m.

Roundtable discussion on future research needs and collaborations
Moderators: Donna Felsenstein, MD and Christine Green, MD

5:30 p.m.

Adjourn Day 1


7:30 a.m.

Continental Breakfast

Session 4: Diagnostic testing for tick-borne diseases: current state and future directions

8:00 a.m.

Overview of currently available tests for Lyme disease and other tick-borne illnesses: strategies and pitfalls
Kurt Reed, MD
University of Wisconsin


Point-of-care testing for Lyme disease: Current approaches and future directions
Kent Lewandrowski, MD
Massachusetts General Hospital

9:15 a.m.

Multiplex assays for tick-borne infections
William Robinson, MD
Stanford University

9:45 a.m.

Mircoarray and next-generation sequencing approaches for diagnosis of borreliosis and other tick-borne infections
Charles Chiu, MD, PhD
University of California-San Francisco

10:15 a.m.


10:30 a.m

Bay Area Lyme Foundation Research Funding Announcement *
(Not part of the educational activity)

Carin Rollins
Bay Area Lyme Foundation

10:35 a.m.

Differential performance of Lyme disease tests on European and North American Borrelia burgdorfi strains
John Branda, MD
Massachusetts General Hospital

11:05 a.m.

Gene expression profiling in Lyme and neuroimmune diseases
Andreas Kogelnik, MD, PhD
Open Medicine Institute


Interlukin 1 beta: a surrogate marker of Borrelia burgdorferi infection
Brian Fallon, MD, PH
Columbia University

12:00 p.m.

Lunch (provided in the Eat Street Cafe, Garden Room)

12:45 p.m.

Novel cellular proteo-stress biomarkers for post treatment Lyme disease syndrome (PTLDS)
Jayakumar Rajadas, PhD
Stanford University

1:15 p.m.

Direct Molecular Detection and Genotyping of Early Lyme Disease from Blood
Mark Eshoo, PhD
Abbott Laboratories

Session 5: Special topics in tick-borne infections

1:30 p.m.

Vaccine development for Lyme disease: past, present and future directions
Stanley Plotkin, MD
University of Pennsylvania

2:00 p.m.

Establishing a biorepository for tick-borne diseases
John Aucott, MD
Johns Hopkins

2:30 p.m.

The Stanford Lyme Disease Working Group: Embracing Diverse Perspectives with Scientific Rigor
Cheryl Koopman, PhD
Stanford University


Summary and Closing Comments
David Torchiana, MD
Massachusetts General Hospital

3:00 p.m.

Adjourn Day 2

Registration Fees

General Admission: $300
Allied Health Professionals: $150
Residents/Fellows: Free (with Group ID to be entered on the next page - please contact Elizabeth Lee-Lewandrowski at elewandrowski@partners.orgto obtain the Group ID)

Cancellation Policy:
Refund requests must be received via email to by October 25, 2014. No refunds will be made thereafter. A $25 handling fee will be deducted for the cancellation.


Accommodation: A limited number of rooms have been reserved at The Wyndham Boston Beacon Hill Hotel, 5 Blossom Street, Boston, MA (Telephone: 617-742-7630) or online at
Please specify that you are enrolled in this course to receive a reduced room rate.

Parking: Complimentary parking is available in the Nashua Street Orange Lot at 99 Nashua Street, Boston, MA
Open 7:00 AM6:00 PM on November 8 & 9


Our Course Coordinator can assist you with any special needs (i.e., physical, dietary, etc). Please contact Elizabeth Lee-Lewandrowski prior to the live event at

For questions regarding registration, please contact Partners Office of Continuing Professional Development at


This program has received support in the form a donation from the Bay Area Lyme Foundation


Provided by:

Massachusetts General Hospital Department of Pathology and Partners HealthCare System

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CME Information


Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Partners HealthCare System designates this live activity for a maximum of12.75 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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