Partners

Founded by brigham and women's hospital and massachusetts general hospital

Office of Continuing Professional Development

Lyme Disease and Other Tick-Borne Illnesses: Clinical Features, Emerging Pathogens and Avenues for New Research

MGH Pathology logo.png

May 14-15, 2016

O'Keefe Auditorium
Massachusetts General Hospital
55 Fruit Street Boston, MA 02114

Description

Lyme disease and other tick--borne illnesses can be difficult to diagnose in their early and late stages, due to the limitations of existing diagnostic tests, confusion about their performance andlack of physician familiarity with the clinical features of these illnesses. There is also controversy concerning the appropriate management of patients who exhibit persistent symptoms following standard regimens of antimicrobial therapy. In addition, there are emerging pathogens that most clinicians have little or no experience in recognizing and treating. The first Partners conference on Lyme Disease and other tick -borne diseases was held in 2014, and focused primarily on diagnostic testing. The vast majority of attendees responded in the post-conference evaluation that they would attend a second conference, and made suggestions for new content. In the second conference we will focus on four main areas:

1. Spirochetal biology and host pathogen interactions
2. Diagnostic testing for tick--borne infections
3. Co-infections and emerging pathogens
4. Clinical features of tick--borne infections

Learning Objectives

Upon completion of this activity, participants will be able to:

1. Demonstrate familiarity with the molecular genetics and cell surface protein biochemistry of the Lyme spirochete
2. Describe the current understanding of host-pathogen interactions in tick-borne infections
3. Review the strengths and limitations of diagnostic tests for tick-borne infections
4. Identify the clinical features of Lyme disease and other tick-borne infections

Target Audience

This program is intended for healthcare providers (internal medicine, pediatrics, infectious diseases, neurology, rheumatology), industry research and development scientists, and clinical investigators.

Agenda

8:00 a.m.

Day 1: Saturday May 14, 2016

Opening Remarks
Elizabeth Lee-Lewandrowski, PhD, MPH
Kent Lewandrowski, MD
John A. Branda, MD

PLENARY LECTURE

8:05

The lengthening list of tick-borne illnesses: what are the research priorities
Alan Barbour, MD
University of California, Irvine

THE BORRELIA SPIROCHETE

8:40

Molecular biology of Borrelia
Patricia Rosa, PhD
National Institutes of Health

9:00

Overview of Borrelia antigens in different stages of the spirochete life cycle
Patricia Rosa, PhD
National Institutes of Health

9:20

Ecology of B burgdorferi
Thomas Mather, PhD
University of Rhode Island

10:00

Question & Answer/Break

TICK-BORNE DISEASES OTHER THAN LYME DISEASE

10:20

Anaplasmosis and Ehrlichosis
Stephen Dumler, MD
Johns Hopkins University

10:40

Borrelia miyamotoi and Borrelia other than burgdorferi
Peter Krause, MD
Yale University

11:00

Babesiosis
Jeffrey Gelfand, MD
Massachusetts General Hospital
Edouard Vannier, PharmD, PhD
Tufts Medical Center

11:20

A map of genetic diversity in Babesia microti and variants associated with relapse
Jacob Lemieux, MD
Massachusetts General Hospital

11:30

Tularemia
Timothy J. Lepore, MD
Nantucket Cottage Hospital

11:45

Bartonella: What evidence is there to suggest this could be a tick-borne illness?
Edward Breitschwerdt, DVM
North Carolina State University
*This presentation is not part of the CME activity, CME credit is not available.

12:00 p.m.

Question & Answer

12:05

1:05

Lunch

Borrelia mayonii and Ehrlichia muris-like agent
Bobbi Pritt, MD
Mayo Clinic

DIAGNOSTIC TESTING FOR TICK-BORNE DISEASES

1:20

Overview of currently available tests for Lyme Disease: Strengths and limitations
John Branda, MD
Massachusetts General Hospital

1:40

Overview of diagnostic tests for tick-borne illnesses other than Lyme disease
Philip J. Molloy, MD
Beth Israel Deaconess Medical Center
*This presentation is not part of the CME activity, CME credit is not available.

2:10

Spatiotemporal cluster analysis of Lyme disease: Implications for positive predictive values in serologic testing
Paul Lantos, MD
Duke University

2:30

Overview of new, highly sensitive analytical technologies with promise to improve Lyme disease diagnosis
William Robinson, MD, PhD
Stanford University

2:55

Question & Answer

3:00

Break

LYME DISEASE AND HOST-PATHOGEN INTERACTIONS

3:15

Host-pathogen interactions in Lyme disease
Klemen Strle, PhD
Massachusetts General Hospital

3:40

Antibiotic resistance in B burgdorferi
Ying Zhang, MD, PhD
Johns Hopkins University

4:00

Mechanisms of spirochete evasion of innate and adaptive immune defenses
Linda Bockenstedt, MD
Yale School of Medicine

4:20

Question & Answer

4:40

Adjourn

*This presentation is not part of the CME activity, CME credit is not available.

8:00 a.m.

Day 2: Sunday May 15, 2016

Opening Remarks
Elizabeth Lee-Lewandrowski, PhD, MPH
Kent Lewandrowski, MD
John A. Branda, MD

8:05

Dysregulation of inflammation and wound repair in post-infectious Lyme arthritis
Robert Lochhead, PhD
Massachusetts General Hospital

8:25

Evidence for the existence of dormant Lyme persister cells
Kim Lewis, PhD
Northeastern University

8:45

Question & Answer

CLINICAL ASPECTS OF LYME DISEASE AND SPECIAL SITUATIONS

8:50

Overview of the clinical aspects of Lyme disease in its various stages
Allen Steere, MD
Massachusetts General Hospital

9:00

Matrix metalloproteinase - 10 is a target of immune responses in both early and late Lyme Disease
Jameson Crowley, PhD

9:20

Cardiac manifestations of Lyme disease
David Dudzinski, MD, JD
Massachusetts General Hospital

9:35

Break

9:50

Neurological manifestations of Lyme disease
John Halperin, MD
Atlantic Health

10:15

Neuropsychiatric manifestations in Lyme disease
Brian Fallon, MD
Columbia University

10:30

Lyme disease in the pediatric patient
Lise Nigrovic, MD
Boston Children's Hospital

10:45

Autoimmune disorders following Lyme disease
Sheila Arvikar, MD
Massachusetts General Hospital

11:00

Post-treatment Lyme disease: What we know and what research is needed. What can we offer the patient with PTLD?
Adriana Marques, MD
National Institutes of Health

11:25

Application of CRISPR technology to control vector-borne diseases
Kevin Esvelt, PhD
Massachusetts Institute of Technology

11:45

Question & Answer

11:55

Bay Area Lyme Foundation Overview *(not part of the educational activity)

12:05

Lunch

1:00 PM

Persistence of Lyme infection after antibiotics: What is the evidence for and against?
Linden Hu, MD
Tufts University
New England Medical Center

1:20

Prevention of tick-borne illnesses
Sam Telford lll, SD
Tufts University

1:40

Rehabilitation approach to post treatment Lyme syndrome
David Crandell, MD
Spaulding Rehabilitation Hospital

2:10

Differential diagnosis: It could be Lyme, but what else should I consider?
Meridale Baggett, MD
Massachusetts General Hospital

SPECIAL TOPICS IN LYME DISEASE

2:30

Vaccine development in Lyme disease: Current state and future directions
Richard Marconi, PhD
Virginia Commonwealth University

2:50

Question & Answer

3:10

Closing Remarks

3:20

Adjourn

Faculty

Course Director
Elizabeth Lee-Lewandrowski, PhD, MPH
Massachusetts General Hospital
Pathology, Laboratory and Molecular Medicine
Harvard Medical School

Course Co-Directors
Kent Lewandrowski, MD
Massachusetts General Hospital
Pathology, Laboratory and Molecular Medicine
Harvard Medical School

John A. Branda, MD
Massachusetts General Hospital
Pathology, Laboratory and Molecular Medicine
Harvard Medical School

Registration Fees

General Admission: $300
Residents/Fellows:Free (with Group ID to be entered on the next page - please contact Elizabeth Lee-Lewandrowski atelewandrowski@partners.orgto obtain the Group ID)

Cancellation Policy:
Registrations cancelled on or before April 30,2016 will be refunded, less a $25administrative fee. Registrations cancelled after April 30, 2016 will not be refunded.

Please contact partnerscpd@partners.org if you require assistance in cancelling your online registration.

Information

Accommodation: A limited number of rooms have been reserved at The Wyndham Boston Beacon Hill Hotel, 5 Blossom Street, Boston, MA (Telephone: 617-742-7630) or online atwww.wyndhambeaconhill.com.

Please specify you are enrolled in the course: Lyme Disease and Tick-Borne Illnesses or the group code: 05136838MGH

Parking:Complimentary parking is available at 99 Nashua Street, Boston, MA

Contact

For questions regarding this activity, please contact Elizabeth Lee-Lewandrowski, PhD at elewandrowski@partners.org or 781--424--1620.

For questions regarding registration, please contact Partners Office of Continuing Professional Development at partnerscpd@partners.org.

Support

This program has received support in the form of a donation from the Bay Area Lyme Foundation

BALF_logo_2014_blue_horiz NEW.jpg

Provided By

Massachusetts General Hospital Department of Pathology and Partners HealthCare System

MGH Pathology logo.png

founding_member.png

CME Information

ACCREDITATION
Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Partners HealthCare System designates this live activity for a maximum of 11.75AMA PRA Category 1 CreditsTM.Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Statement

This website uses Echo360 technologies. Echo360 partners with the world’s leading educational institutions and industry associations to enhance the teaching and learning experience for students and professionals like you. Our goal is to enable a more engaging and successful learning experience by providing you with live and on-demand access to study tools, videos, and collaboration capabilities in an online classroom to help you achieve your educational goals. We believe you should always know what data we collect from you and how we use it. As part of our ongoing commitment to transparency, and to support new European data protection laws, we're updating our Privacy Policy to inform you about the information that you share with us. The revised policy will take effect on May 25, 2018. By using our services on or after that date, you'll be agreeing to these updates. We encourage you to read this document in full. Echo360, Inc. 11955 Freedom Drive, Suite 700, Reston, VA 20190 USA