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Office of Continuing Professional Development

Massachusetts Alzheimer's Disease Research Center's 30th Anniversary Symposium

REGISTRATION IS CLOSED

PLEASE CONTACT PARTNERSCPD@PARTNERS.ORG TO BE PLACED ON THE WAITLIST

MGH Neurology

Friday, September 19, 2014; 8:45am – 5:30pm

Richard B. Simches Research Center, Suite 3.110

Massachusetts General Hospital

185 Cambridge Street

Boston, MA 02114

Description

The Massachusetts Alzheimer’s Disease Research Center was one of the first three Alzheimer’s Disease Centers that were funded in 1984 under the PHS Act, Section 445, when Congress mandated the NIA to set up a nationwide ADC program to pursue research related to the disease, in anticipation of the ‘silver tsunami’ that is expected to overwhelm the U.S. public health system.  

This live symposium will feature presentations by some of the most preeminent leaders in the field of AD research and clinical practice – many of whom were trained at the Center – on four major topics:  Neuroimaging, Genetics, Therapeutics and Future Directions in AD Research. Major advances in research and treatment paradigms over the past 30 years will be discussed, along with discourse on ‘next-generation’ R & D (‘Research & Development’) approaches that will mine ‘Big Data’ from cross-disciplinary teams to translate research findings to effective therapeutics for patients with AD.

Learning Objectives

Upon completion of this activity, participants will be able to:

1.  Delineate state-of-the-art neuroimaging approaches that are currently used in the field of AD, and apply such knowledge to their own research enterprise and/or clinical practices
2.  Interpret existing challenges in designing next-generation neuroimaging technologies for use in the AD and related neurodegenerative diseases sector
3.  Identify state-of-the-art genomic, biomarker and epigenetic breakthroughs that are current in the field, and translate such knowledge to their own research enterprise and/or clinical practices
4.  Integrate ongoing large-scale, multidisciplinary genomic, proteomic and metabolomics initiatives led by Center personnel and other leading experts in the neurodegenerative diseases sector
5.  Apply novel basic and translational therapeutic approaches that are currently pursued in the AD field, and integrate such knowledge to their own research enterprise and/or clinical practices

Target Audience

This activity is intended for physicians, nurse practitioners, physician assistants, nurses, pharmacists, psychologists, social workers, researchers (PhDs), medical students, other mental health professionals, and complementary and alternative medicine practitioners.

Agenda

8:45am           

Opening Remarks                  
Bradley T. Hyman, MD, PhD
Joseph B. Martin, MD, PhD
Creighton H. Phelps, PhD

Imaging

Chair: Clifford R. Jack, Jr., MD & Bruce R. Rosen, MD, PhD

9:15      

In vivo Imaging of Tau Deposition
Keith A. Johnson, MD

9:40    

Brain Networks and Neurodegeneration      
Randy L. Buckner, PhD

10:05

How Do Imaging Studies Inform On Relationships between AD and Other Age-Associated Processes that Lead to Cognitive Decline
Clifford R. Jack, Jr. MD

10:30

Coffee Break

Genetics

Chair: Peter St. George-Hyslop, MD, FRS, FRSC, FRCPC & Joseph B. Martin, MD, PhD

11:00  

Alzheimer's Disease: From Genes to Therapies in the Whole Genome Era
Rudolph E. Tanzi, PhD

11:30  

Functional Genetics of Alzheimer's Disease
Peter St George-Hyslop, MD, FRS, FRSC, FRCPC            

12:00 pm        

Luncheon
Location:  TBA

Therapeutics

Chair:  Dennis J. Selkoe, MD

1:30                                               

Immunotherapy for Neurodegenerative Diseases    
Roger M. Nitsch, MD

1:55                

Loss of Function of TREM2, a Common Mechanism of Neurodegeneration
Christian Haass, PhD

2:20                

Can We Detect and Treat Alzheimer’s Disease a Decade Before Dementia?
Reisa A. Sperling, MD, MMSc

2:45

Coffee Break

Future Directions in Alzheimer’s Research

Chair: Zaven S. Khachaturian, PhD & Anne B. Young, MD, PhD

3:15    

Understanding Human Brain Resilience to Alzheimer's Pathology
M. Teresa Gomez-Isla, MD, PhD

3:40                

The Nose Knows: Early Events in Alzheimer's Disease
Mark W. Albers, MD, PhD

4:00                 

Apolipoprotein E, a Factor of Brain resilience and Susceptibility in Alzheimer's
Eloise Hudry, PhD

 4:20

Network Dysfunction in Dominantly Inherited and Sporadic, Late Onset AD
Jasmeer Chhatwal, MD, PhD

 4:40

APP and PSEN1 Mutations Induce β-Amyloid and Tau Pathologies in a3D Human Neural Cell Culture System: A Late-Stage Alzheimer’s Disease Model in a Dish
Doo Yeon Kim, PhD                                                     

5:00    

Concluding Remarks:  Looking Ahead
Bradley T. Hyman, MD, PhD
John H. Growdon, MD

5:30pm                       

Symposium Adjournment

Registration Information

This activity is free of charge.

Faculty

Mark W. Albers, MD, PhD
Frank Wilkens Jr. and Family Endowed Chair in Alzheimer’s Disease Research
Assistant Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Randy L. Buckner, PhD
Director, Psychiatric Neuroimaging Research Program
MGH-HST Athinoula A. Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Professor of Psychology and Neuroscience, Faculty of Arts and Sciences
Harvard University
Professor of Psychology, Department of Psychiatry
Massachusetts General Hospital/Harvard Medical School

Jasmeer Chhatwal, MD, PhD
Instructor in Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

M. Teresa Gomez-Isla, MD, PhD
Co-Director, Clinical Core, Massachusetts Alzheimer’s Disease Research Center
Co-Director, Memory Disorders Unit
Massachusetts General Hospital
Associate Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

John H. Growdon, MD
Founding Director, Massachusetts Alzheimer’s Disease Research Center
Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Christian Haass, PhD
Chair, Metabolic Chemistry
Adolf-Butenandt Institute
Head, Laboratory of Neurodegenerative Disease
Professor of Biochemistry
Ludwig-Maximilians University, Munich
Speaker, German Center for Neurodegenerative Diseases (DZNE)

Eloise Hudry, PhD
Instructor in Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Bradley T. Hyman, MD, PhD
Director, Massachusetts Alzheimer’s Disease Research Center
Co-Director, Memory Disorders Unit
Massachusetts General Hospital
Vice-Chair for Research, Department of Neurology
Massachusetts General Hospital
John B. Penney Jr., Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School
Member, National Advisory Council on Aging
National Institute on Aging/National Institutes of Health

Clifford R. Jack, Jr., MD
Alexander Family Professor of Alzheimer’s Disease Research
Professor of Radiology
Mayo Clinic

Keith A. Johnson, MD
Co-Director, Neuroimaging Core, Massachusetts Alzheimer’s Disease Research Center
Director, Molecular Neuroimaging Program
Massachusetts General Hospital
Professor of Radiology, Department of Radiology
Massachusetts General Hospital/Harvard Medical School

Zaven S. Khachaturian, PhD
Senior Associate, Khachuturian & Associates, Inc.
Senior Science Advisor, Alzheimer’s Association
Editor-in-Chief, Alzheimer’s Dementia: The Journal of the Alzheimer’s Association
President & Chairman, The Campaign to Prevent Alzheimer’s Disease by 2020

Doo Yeon Kim, PhD
Assistant Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Joseph B. Martin, PhD, MD
Former Chair, Department of Neurology and Neurosurgery
McGill University
Former Chair, Department of Neurology
Massachusetts General Hospital
Interim Director
Massachusetts General Hospital
Former Dean, School of Medicine
University of California, San Francisco
Former Chancellor
University of California, San Francisco
Former Dean, Faculty of Medicine
Harvard Medical School
Edward R. and Anne G. Lefler Distinguished Professor of Neurobiology, Department of Neurobiology
Harvard Medical School

Roger M. Nitsch, MD
Director, Division of Psychiatry Research
Professor of Molecular Psychiatry
University of Zurich

Bruce R. Rosen, PhD, MD
Director, MGH-HST Athinoula A. Martinos Center for Biomedical Imaging
Professor of Health Sciences and Technology
Harvard University
Lawrence Lamson Robbins Professor of Radiology, Department of Radiology
Massachusetts General Hospital/Harvard Medical School

Dennis J. Selkoe, MD
Co-Director, Center for Neurologic Diseases
Vincent and Stella Coates Professor of Neurologic Diseases, Department of Neurology
Brigham and Women’s Hospital/Harvard Medical School

Reisa A. Sperling, MD, MMSc
Director, Center for Alzheimer Research and Treatment
Co-Director, Neuroimaging Core, Massachusetts Alzheimer’s Disease Research Center
Co-Director, Outreach, Recruitment & Education Core, Massachusetts Alzheimer’s Disease Research Center
Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School
Member, National Advisory Council on Aging
National Institute on Aging/National Institutes of Health

Peter St. George-Hyslop, MD, FRS, FRSC, FRCPC
Director, Tanz Centre for Research in Neurodegenerative Diseases
University Professor, Faculty of Medicine
University of Toronto
Professor of Experimental Neuroscience, Cambridge Institute for Medical Research
University of Cambridge

Rudolph E. Tanzi, PhD
Director, Genetics and Aging Research Unit
MassGeneral Institute for NeuroDegenerative Disease
Massachusetts General Hospital
Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Anne B. Young, MD, PhD
Former Chair, Department of Neurology
Massachusetts General Hospital
Director, MassGeneral Institute for Neurodegenerative Disease
Julieanne Dorn Professor of Neurology, Department of Neurology
Massachusetts General Hospital/Harvard Medical School

Contact

For questions regarding the online registration process, please contact Partners HealthCare Office of Continuing Professional Development at phscme@partners.org or 617-535-6430.

For additional registration questions, please contact Liang Yap, PhD at lyap@partners.org or 617-726-3987.

Do you have any special needs (e.g., ADA, Dietary, Allergies)? If yes, please contact Liang Yap, PhD at lyap@partners.org or 617-726-3987.

Provided by:

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CME Information

Accreditation
Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. 

Partners HealthCare System designates this live activity for a maximum of 6.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.